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While oral semaglutide was cost-effective compared to liraglutide (ICER = $40,100/QALY) and moderately cost-effective versus background treatment ($117,500/QALY) and sitagliptin ($145,200/QALY), it did not meet standard cost-effectiveness thresholds when compared with empagliflozin, with an estimated ICER of approximately $458,400 per QALY
But for reconstituted solution, freezing is destructive
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