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Peer review Peer review information Nature Reviews Endocrinology thanks Steven Heymsfield, Luis Moreno and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Previous reports have shown the reduction of aldehydes into alcohols using NADH as a hydride source 15 , NAD + into NADH using formate as a hydride source 16 , pyruvate into lactate using formate as a hydride source 17,18 , or ally alcohols into ketones 19