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Long-term use may reduce zinc levels

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They reported increased peripheral levels of TNF- converting enzyme, IL-1, IL-2, IL-6, IL-18, interferon-gamma (IFN-), homocysteine, high-sensitivity CRP, CCL10, epidermal growth factor (EGF), vascular cell adhesion molecule-1 (VACM-1), TNF receptor1/2, and 1-antichymotrypsin in AD patients as compared with the levels in the control subjects (Lai et al., 2017)