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Oral semaglutide overcomes this through a technology called SNAC (sodium N-[8-(2-hydroxybenzoyl)aminocaprylate]) a compound co-formulated with semaglutide that temporarily raises the local pH in the stomach lining and facilitates absorption directly through the gastric mucosa, bypassing the destructive environment of the small intestine

The review also highlights the success of these synthetic medications in treating comorbidities

Similarly, Semaglutide GLP-1, marketed as Ozempic, generally costs slightly higher, ranging from $850 to $950 for a one-month supply without insurance