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Cu(II) is held in a square-planar coordination sphere by the N-terminal amine, the deprotonated glycyl amide nitrogen and the histidine imidazole, at a stability constant (log K approximately 16.4) close to that of the copper transport site on human serum albumin

In the context of water retention, individuals with certain FTO and MC4R variants may show more pronounced metabolic improvement and potentially faster fluid normalization