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One trial involving 24 Asian women used a cream with niacinamide 5%, tranexamic acid 2%, oxyresveratrol 2%, glutathione disulfide 2%, and linoleic acid 1% applied twice daily

Cells were seeded at a density of 5000 cells per well in 200 l fresh culture medium (DMEM supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin solution) into 96-well flat-bottomed microtitre plates (Costar, Corning, USA) and incubated at 37 C in humidified 5% CO 2 using AutoFlow NU-5510 Direct Heat CO 2 Incubator (NuAire, USA) for 24 hours before treatment

Even so, doctors expect peptide use to spike, despite lack of evidence that all of these substances work or are safe

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