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These drugs disrupt the autocrine and paracrine signaling pathways between these cells, ultimately resulting in alterations to cardiac cell homeostasis ( 4.3.2 Doxorubicin Doxorubicin (DOX), a widely employed chemotherapeutic agent, is nonetheless limited in its clinical application due to its significant cardiotoxicity

Initial PK profiling was performed in mice, using both IV (2 mg/kg) and oral (10 mg/kg) routes