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We hypothesized that one particular class of hydrogel materials, PNP hydrogels, would be particularly well suited for this purpose and would exhibit several important features: (i) facile formulation with important GLP-1 RAs such as semaglutide and liraglutide, (ii) patient convenience in the form of straightforward injectability with standard syringes and needles, (iii) excellent tolerability by maintaining consistent slow release to circumvent undersirable gastrointestinal side-effects, and (iv) four months of continuous therapy per administration

For those unfamiliar with why this happens, the discomfort can feel alarming and lead to premature discontinuation of an otherwise well-designed protocol

Susanne Clara Bard, UC San Diego Beyond the widespread attention GLP-1 drugs are receiving for treating obesity, lowering blood sugar and decreasing the risk of cardiovascular disease, emerging research is investigating their other potential impacts including their effects on aging

This question concerns many patients prescribed tirzepatide for type 2 diabetes management