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Instead, it has the ability to engage with several of them

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The problem: very short half-life (~50 minutes) and 3 daily injections at meals , an extremely impractical regimen

Cells were transfected with equal amounts of GCGR, GsS-, Gi1-, Gi2-, Gi3-, GoA-, GoB- or Gz-Rluc8, G3, and G1-, G8- or G9-GFP2 (as described in [21]), and pcDNA3.1() using polyethyleneimine (ESM Table 3)