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2019;143(1):111e-e120

This design facilitates precise therapeutic delivery, improving bioavailability and reducing systemic toxicity

TH potentiates the production of non-12-OH FXR-antagonistic BAs Recent evidence suggests that a couple of non-12-OH BAs, including T(/)MCA, (T/G)UDCA, and (T)HDCA, can exert FXR-antagonistic effects 4,9,10,29 , while intestinal FXR inhibition is able to stimulate GLP-1 production and secretion in L cell 11

L-Carnitine reduces myocardial oxidative stress and alleviates myocardial Ischemia-Reperfusion injury by activating nuclear Transcription-Related factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1) signaling pathway