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Hu ML, Rayner CK, Wu KL, et al
The coordinated nature of these pathway disruptions is particularly significant, as CSCs often demonstrate remarkable plasticity and can maintain their stem-like properties through compensatory activation of alternative signaling routes when individual pathways are targeted in isolation
Instead, these FDA-approved medications work primarily by reducing appetite, slowing gastric emptying, and decreasing caloric intake
C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve -cell function
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