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Although our synthesis shows increased gastrointestinal AEs and treatment discontinuation related to AEs, these challenges can generally be managed in practice through low-dose initiation, gradual up-titration, and regular monitoring 49
Tirzepatide works by mimicking two metabolic hormones in the body: it acts as a glucagon-like peptide-1 (GLP-1) receptor agonist and also as a glucose dependent insulinotropic polypeptide (GIP) receptor agonist
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