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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007
The recommended B12 dosage is as follows: Men over 14 years of age should consume 2.4 mcg daily Women over 14 years of age should also consume 2.4 mcg daily Pregnant Women should consume 2.6 mcg daily Lactating Women should consume 2.8 mcg daily Be sure to discuss your interest in B12 with a medical professional prior to beginning any supplementation
PMID: 25730455
This detox phase may usher in mild symptoms
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