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Thyroid cancer risk: There is a boxed warning about the risk of thyroid C-cell tumors and medullary thyroid cancer associated with some GLP-1 agonists, based on animal studies

In particular, incomplete retrieval of grey literature and insufficient documentation of study-exclusion decisions could lead to overestimation of benefits or underdetection of harms, while the infrequent propagation of primary-study bias into meta-analytic models reduces confidence in the magnitude of pooled effects

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