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When coupled to -arrestins, GPCRs are desensitized by abrogated coupling to G proteins and trafficked away from the cell surface, destined for either re-sensitization following their recycling back to the plasma membrane, or for final signal termination resulting from their degradation in lysosomes (McCorvy et al., 2017)

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Patients who maintain treatment for years tend to have visibly fewer static lines than peers who dont
When appetite is limited, they're the ones that pull double or triple duty
