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The complex, multi-component nature of targeted and stimuli-responsive nanoplatforms complicates large-scale production, rigorous quality control, and the evaluation of long-term biocompatibility for novel biomaterials and metal-based nanoparticles (59, 68)

The copper component serves as an essential cofactor for lysyl oxidase and lysyl hydroxylase, enzymes critical for proper collagen cross-linking and stability

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[10] Possible Repigmentation Enhancement : Experimental data highlight MT-1s ability to stimulate melanocytes and support melanin synthesis