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Clifford Rosen, a professor of medicine at Tufts University who was not involved in the study, said that across the millions of people now taking GLP-1s, the overall population-level risk is small
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Contraindications include personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, as GLP-1 agonists have shown thyroid effects in animal models
While circulating levels of PYY 3-36 are frequently reduced in individuals with obesity 31,32,33,34,35 , these levels typically return to those detected in average-weight individuals following a reduction in body weight and/or gastric bypass surgery 32,33,35
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