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They report obvious narratives of reduced hunger, fewer snacks, and not constantly thinking about food
From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models
It cites the PIONEER program and says participants at the highest daily amount achieved roughly 10 to 12 percent body weight reduction, within an overall range of 5 to 12 percent
Genetic variants in NAT2, GST, and CYP2E1 influence metabolic rates but don't predict toxicity alone
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