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Patients losing significant weight may experience various physiological adjustments, but these do not constitute immune system suppression

Mazdutide Shows Superiority in Glycemic Control with Weight Loss over Semaglutide in a Head-to-head Phase 3 Clinical Trial DREAMS-3. Innovent Biologics Press Release , October 2025

Talk to your doctor to determine if semaglutide is right for you for safe, efficient weight loss

Historically, a complex bidirectional communication system between the gastrointestinal tract, its microbiota, and the CNScomprising neural, hormonal, and immune pathwayshas been recognized and termed the MGB axis (51)