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In 1998, Anisimov and Khavinson collaborated on a study that, as described in an article published by the The Longevity Research Institute (LRI), examined the effect of epithalamin, a pineal peptide preparation, on the lifespan of fruit flies, mice, and rats

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or Polycitra a combination of citric acid, potassium citrate, and sodium citrate) has been used as an oral medication to help maintain plasma bicarbonate levels within the reference range (or alternatively very large doses of bicarbonate may be used)