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Heartburn that does not respond to lifestyle changes or standard management

Yes, semaglutide may interact with certain medications, especially those affecting blood sugar levels or digestion

Herbette S, Lenne C, Leblanc N, Julien J-L, Drevet JR, Roeckel-Drevet P (2002) Two GPX-like proteins from Lycopersicon esculentum and Helianthus annuus are antioxidant enzymes with phospholipid hydroperoxide glutathione peroxidase and thioredoxin peroxidase activities