Lofgren S, Fernando MR, Xing KY, Wang Y, Kuszynski CA, Ho YS et al
39 In astrocytes, GSH serves as a reservoir for cysteine, glycine, and glutamic acid, each with their own biochemical activities
Its introduction into clinical practice offers a new horizon for improving metabolic outcomes in patients, with a favorable impact on CV risk factors
3.2.7 Other PD-related genes/proteins potentially associated with ferroptosis The absence of CISD1, an iron-rich outer mitochondrial membrane protein, triggers mitochondrial dysfunction alongside the depletion of striatal dopamine and TH, thus facilitating the advancement of PD and the worsening of its clinical manifestations (172)