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Both drugs activate the same GLP-1 and GIP receptors, so combining them would create overlapping and potentially dangerous receptor overstimulation
MHRA-licensed alternatives for weight management including semaglutide (Wegovy), liraglutide (Saxenda), orlistat, and tirzepatide (Mounjaro) have well-characterised safety profiles and NICE eligibility criteria
3 This approach is often referred to as a continuum of care, meaning treatment is not a single intervention but an ongoing, coordinated pathway that evolves over time
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