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Concomitantly, autophagy was reported to also reduce the hepatocyte apoptosis caused by steatosis and endoplasmic reticulum stress, possibly through the GLP-1RA-stimulated GLP-1R-mediated activation of the EB transcription factor of the autophagy-lysosome pathway, thus reducing the accumulation of liver lipids (201)

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Consequently, GIP receptor antagonism was proposed as a potential strategy for treating obesity-related diabetes (73)

Sensitivity analysis PP, repeated-measures and inverse probability weighting analyses were consistent with the primary outcome analysis (Supplementary Information)