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[PMID: 37688299]
In comparison to the placebo group, T2DM subjects post-3 months supplementation with L-GSH had a significant several-fold increase in the production of both IFN- ( Figures 6B, C ) and TNF- ( Figures 6D, E ) in the granuloma supernatants from the L-GSH group at both 8-days and 15- days post in vitro BCG infection
This situation would lead to a self-perpetuating cycle, in which the free radicals generated would induce GSH depletion, thus increasing oxidative stress that would reduce antioxidant enzyme levels, which would further reduce GSH synthesis
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