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In addition, the application of phosphate fertilizers, excess industrial chemical waste, and sewage sludge are actively involved in increasing HMs-toxicity to plants, soils, and environments [3, 4]

Graphical Abstract Similar content being viewed by others Introduction Professor Ernest Starling proposed the idea of using a gut hormone for the treatment of diabetes in London in the early 1900s and this idea was first tested by administering gut extracts to individuals with the disease [1]

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