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Clinical and preclinical trials demand microbiome-targeted strategies which should necessarily be based on rigorous, widespread, large-scale, and long-term experiments to further validate the safety and efficacy
D.) 354 (Academic Press, 2006)
The clever part
They are subsequently degraded in the proteasome and translocated into the nucleus where they bind to specific DNA sequences and initiate the transcription of target genes involved in the immune response, inflammation (e.g., tumor necrosis factor (TNF)-, ILs 1 and 6, prostaglandins), chemotaxis (e.g., IL-8), cell adhesion (intercellular adhesion molecule-1, vascular adhesion molecule-1), growth regulation, and apoptosis resistance
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