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On Monday, 24th November, Novo Nordisk published a press release, explaining that the Evoke and Evoke+ trials did not confirm superiority of semaglutide versus placebo in the reduction of progression of Alzheimers disease. Although the researchers did report significant reductions in biomarkers associated with Alzheimers, there was no reduction in disease progression in either trial

It competes with sulfate-reducing bacteria for resources, effectively crowding them out over time

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Resident microglia are considered part of the NVU due to their capacity to modulate BBB function in response to changes associated with various conditions