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For example, the addition of semaglutide at a dose of 0.5 mg or 1 mg per week in patients receiving basal insulin resulted in a 1% and 1.8% decrease in HbA1c, respectively, in SUSTAIN- 5

Semaglutide can impact gastric emptying and blood glucose regulation, thus care teams will frequently institute a waiting period to reduce surgical risk

Injection Site Reactions: Redness or swelling, resolving quickly from local activation

So when it comes to transdermal preps, which are still systemic, so theyre being absorbed like those orals, um, but they are associated with a lower clot risk than oral estrogens, since the transdermal preps avoid that absorption in the stomach and the metabolism in the liver