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COVID-19 and toll-like receptor 4 (TLR4): SARS-CoV-2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation
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For example, severe neuroinflammation (brain fog) can dysregulate the autonomic nervous system, leading to worsened POTS symptoms (tachycardia), which in turn triggers mast cell degranulation (histamine release)
Maximum results usually occur after 4-6 months of regular application
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