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Invest Ophthalmol Vis Sci 55(4):23922402 Singh S et al (2021) Povidone-Iodine attenuates viral replication in ocular cells: implications for ocular transmission of RNA viruses

3.3.2 Nrf2 activators The activation of Nrf2-ARE signaling pathway also plays an important role in protecting against mitochondrial dysfunction through promoting mitophagy (Ran et al., 2022)

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Because no long-term human safety data exists, the conservative clinical approach treats cycling as a prudent default rather than a proven necessity