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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
318,319 One study revealed that CP31398 could facilitate the binding of mutant p53 to p53 response elements in vivo and restore the DNA-binding activity of mutant p53 in vitro
As a result, a less extensive safety database exists for their use in obesity relative to type 2 diabetes, leaving providers with many unanswered questions
Both approaches enhance wound healing through different mechanisms
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