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The effect was dose-dependent and distinct from PDE5 inhibitors because it works centrally, through hypothalamic MC4R activation rather than peripheral vasodilation (Hadley, 2005)
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Ideal candidates should also be evaluated for their overall health status, ensuring they do not have any contraindications such as a history of pancreatitis, severe gastrointestinal issues, or certain chronic illnesses that could be exacerbated by the medication
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