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In addition, a recent revision of the studies examining the risk factors associated with disease severity showed that preexisting conditions like chronic obstructive pulmonary disease (COPD), cardiovascular disease, diabetes mellitus, hypertension, chronic kidney failure, cancer and a history of smoking are tightly and positively associated with a more severe course of COVID-19 27

Exogenous (from the outside) : Symptoms appear after exposure to synthetic progestins 4 , including those found in contraceptives like birth control pills or fertility medications