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Reviews of the preclinical literature describe effects across skin and other connective tissues, although much of this evidence comes from cellular or animal models rather than controlled human treatment trials.[5] What the human skin evidence for GHK-Cu actually shows The published human evidence for topical GHK-Cu is limited

HMGCS1, 3-Hydroxy-3-methylglutaryl-CoA synthase 1

ROS include oxygen free radicals, such as superoxide anion, hydrogen peroxide, hydroxyl radical and free nitrogen radicals (27)

PubMed Detoxification & Xenobiotic Metabolism GSH functions as a detoxification agent through the mercapturic pathway