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Both multivariate and univariate analysis of HbA1c at 3 and 9 months showed no significant differences between groups (Supplementary Table 5.1, Supplementary Table 5.3, Table 2) HbA1c values at 12 months were not collected for 9/27 participants (33.3%) (Fig

The 2000s marked a mechanistic leap, as it was demonstrated that suppression of nocturnal melatonin through LAN enhanced BC cellular metabolism and growth in breast cancer xenografts, providing compelling evidence of a link between circadian biology and tumor progression 52,53,54

Tissue ribbons were placed onto slides, which were then baked, deparaffinized using xylene, and hydrated in graded ethanol, followed by antigen retrieval in Citrate Antigen Retrieval solution

This review integrates current evidence on microbial homeostasis, dysbiosis, disease mechanisms, and translational applications, with an emphasis on how mechanistic insights can inform microbiota-based biomarkers and therapeutic strategies