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-KG activates prolyl hydroxylases (PHDs) that stabilize hypoxia-inducible factor 1 (HIF-1) (Martnez-Reyes and Chandel, 2020)

They observed liver injury at therapeutic concentrations 4 M TVX, which was indicated by decreased ATP levels after 7 days of treatment

Subsequently, the LtGPX3::NEO plasmid was transformed into protoplasts of Ltgpx3
