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p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]
rodentium -triggered colonic inflammation (42) as well as genetically-driven colitis observed in IL-10 -/- mice (48)
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