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Concerning glioblastoma (GBM), it has been reported that transient transfection of miR-34a mimics into glioma and medulloblastoma cell lines remarkably inhibits cell proliferation, invasion, survival, and cell cycle progression by targeting c-Met, Notch-1, and Notch-2 (Li Y

10.1016/S0896-6273(00)80466-3 Neuron 115 MainaF.HiltonM

Month 1: initial assessment Run a basic metabolic panel and fasting glucose at 4 weeks, just before your first dose escalation from 2.5 mg to 5 mg