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It is not controlled by a single enzyme

For example, research has shown that the GLP-1 receptor agonist liraglutide can alleviate pain hypersensitivity in chronic migraine models by stimulating interleukin-10, suggesting its potential to modulate central sensitizationa crucial mechanism in chronic pain 62

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DPP-4 inhibitors which increase levels of GLP-1, a hormone that helps reduce blood sugar levels have been approved for treatment of type 2 diabetes since 2006