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Symptoms such as fatigue, numbness, weakness, memory changes, and balance problems can have many causes
To understand the underlying mechanisms, inhibitors targeting the Notch pathway (DAPT) and NF-B pathway (BMS) were also applied to HUVEC and murine CLI models
Less burying behavior without increased shock reception suggests enhanced coping rather than fear suppression
high SAM availability can trigger compensatory or context-dependent metabolic responses rather than simply increasing all methylation reactions in a linear manner
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