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While both Semaglutide and Tirzepatide are generally well-tolerated, common side effects may include nausea, diarrhea, and occasional injection site reactions
The observed sex differences in the outcomes of long-term semaglutide treatment in GAN DIO-MASH mice are likely species-specific, as no differences have been reported in response rates to semaglutide between female and male participants with MASH in the phase 3 clinical trial (27)
A study in Nature Medicine found that plasma levocarnitine levels predicted increased cardiovascular risk only among subjects with concurrently high TMAO levels
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