Over the past two decades, therapies based on incretin hormones, spearheaded by glucagon-like peptide 1 (GLP1) receptor agonists (GLP1RAs), have become the treatment of choice for obesity and T2DM, and clinical evidence now suggests that these agents have benefits for CVD
These include: Nausea and vomiting Diarrhoea Reduced appetite and fluid intake These effects can lead to inadequate hydration and depletion of essential electrolytes such as sodium, potassium, magnesium, and calciumall of which are crucial for normal muscle function
Patients who make meaningful lifestyle changes alongside treatment are likely to see greater and more sustained results
Risks factors include age under 24 months (especially those with organic brain disease), developmental delay, coincident congenital metabolic disorders, previous liver dysfunction, or severe epilepsy treated with polytherapy or ketogenic diets [23, 51, 52]