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Study on the treatment of diabetic foot ulcer with polysaccharide from pseudostellaria heterophylla in rats
This may include: Neurological exam to rule out focal deficits Fundoscopic exam to check for papilledema MRI brain with and without contrast if red-flag features present Lumbar puncture with opening pressure measurement if idiopathic intracranial hypertension suspected Discussion of temporary dose reduction or treatment pause Why the headache gets worse during dose escalations The dose-response relationship for GLP-1 headaches is real but modest
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For the day 1 clinical measure scores (MADRS, QIDSSR, M3VAS, SHAPS, TEPS-A and TEPS-C), linear mixed-effects models were also used with condition (placebo and naltrexone), time (preinfusion and day 1 postinfusion), visit (visit 1 and visit 2) and the interaction between condition and time as fixed effects
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