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Their regulatory approval for obesity (liraglutide in 2014 and semaglutide in 20212022) may also contribute to the predominance of older individuals among treated people [3, 18, 19]

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In the interim, the supply-demand imbalance in high-purity GLP-1 peptide CDMO capacity is giving existing capacity holders unprecedented pricing power and making multi-year capacity reservation agreements with take-or-pay clauses the standard commercial structure for late-stage peptide programmes

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