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They have the potential to be early biomarkers for PD, with symptoms such as olfactory dysfunction, sleep problems, constipation, and erectile dysfunction often predating the diagnosis of PD by years [14,15]

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This may mediate activation of perivascular Ms, microglia, and astrocytes, and initiate further immune responses within the brain parenchyma, suggesting neuroinflammation can be triggered by signaling from the periphery, without primary injury or disease originating within the CNS

The best results are achieved when the patient is in good health, but desires body-slimming in those resistant areas