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Genetic variation in GLP-1 receptor structure (rs6923761), GLP-dependent insulinotropic polypeptide signaling (GIPR rs1800437), and metabolic regulators like FTO (rs9939609) influence both drug efficacy and side effect severity

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The hierarchical taxonomy of psychopathology (HiTOP): a quantitative nosology based on consensus of evidence

At 68 weeks, patients on retatrutide 12 mg lost an average of 28.7% of their body weightequivalent to 71.2 lbs (32.3 kg) from a baseline weight of around 248 lbs