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Significant uncertainty surrounds these assumptions, particularly those regarding future uptake rate and the effectiveness and persistency of these medications

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In the 2025 study mentioned earlier, women receiving the combination therapy experienced an average weight loss of 6.09 kg (about 13.4 lbs) over 16 weeks, compared to 2.25 kg (approximately 5.0 lbs) in the metformin-only group

Here's exactly how it went: Related: "I Tried GLP-1s For 8 WeeksHere's My Honest Experience" On day 1, I held the needle for 20 minutes, and couldn't do it