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Supplements that claim to contain only R -lipoic acid are usually more expensive, and information regarding their purity is not publicly available (109)

For topical products, the relevant question is not plasma half life but dermal residence time, which depends almost entirely on the delivery vehicle

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Intramuscular injection may be clinically preferable to oral supplementation in specific situations: For individuals whose bloodwork shows deficiency or insufficiency in B12, vitamin D, or other measurable nutrients, and who have not achieved adequate levels through oral means