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Animal reproduction studies with semaglutide have shown embryofetal toxicity, including structural abnormalities, at exposures below those expected at therapeutic doses in humans
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Its cytoprotective mechanisms in this context are multifaceted: it bypasses the prostaglandin pathway, maintains endothelial integrity to ensure blood flow to the mucosa, and directly stimulates the cellular processes required for repair
Local injection near the injury site delivers high peptide concentrations directly to affected tissues
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